Pathogenesis and Host Response

TOPIC: PATHOGENESIS & HOST RESPONSE

📌 POINTS TO PONDER

🔹 Systemic diseases associated with neutrophil disorders and periodontal diseases are diabetes mellitus, Papillon-Lefevre syndrome, Down syndrome, Chediak-Higashi syndrome, drug induced agranulocytosis, cyclic neutropenia and leukocyte adhesion deficiency.

🔹Periodontal diseases with neutrophil disorders areNUG, localized aggressive periodontitis and refractory periodontitis.

🔹Chemokine paralysis: P. gingivalis impedes transepithelial migration of neutrophils and prevent epithelial cells from secreting IL-8 in response to bacterial challenge. This property may contribute to the virulence of P. gingivalis by interfering with the host immune response.